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Pharmacogenomics

Publications

Selected publications

  1. Kuguyo O, Tsikai N, Thomford NE, Magwali T, Madziyire MG, Nhachi CFB, Matimba A, Dandara C. Genetic Susceptibility for Cervical Cancer in African Populations: What Are the Host Genetic Drivers? OMICS. 2018 Jul;22(7):468-483. doi: 10.1089/omi.2018.0075.

 

  1. Thomford NE, Dzobo K, Chimusa E, Andrae-Marobela K, Chirikure S, Wonkam A, Dandara C. Personalized Herbal Medicine? A Roadmap for Convergence of Herbal and Precision Medicine Biomarker Innovations. OMICS. 2018 Jun;22(6):375-391. doi: 10.1089/omi.2018.0074.

 

  1. Soko ND, Masimirembwa C, Dandara C. A cost effective RFLP method to genotype Solute carrier organic anion 1B1 (SLCO1B1) c.1929A>C (p.Leu643Phe, rs34671512); a variant with potential effect on rosuvastatin pharmacokinetics. BMC Res Notes. 2018 Jun 14;11(1):384. doi: 10.1186/s13104-018-3469-4.

 

  1. Dzobo K, Hassen N, Senthebane DA, Thomford NE, Rowe A, Shipanga H, Wonkam A, Parker MI, Mowla S, Dandara C. Chemoresistance to Cancer Treatment: Benzo-α-Pyrene as Friend or Foe? Molecules. 2018 Apr 17;23(4). pii: E930. doi: 10.3390/molecules23040930.

 

  1. Kuguyo O, Matimba A, Tsikai N, Magwali T, Madziyire M, Gidiri M, Dandara C, Nhachi C. Cervical cancer in Zimbabwe: a situation analysisPan Afr Med J. 2017 Jul 21;27:215. doi: 10.11604/pamj.2017.27.215.12994. eCollection 2017.

 

  1. Thomford NE, Dzobo K, Adu F, Chirikure S, Wonkam A, Dandara C. Bush mint (Hyptis suaveolens) and spreading hogweed (Boerhavia diffusa) medicinal plant extracts differentially affect activities of CYP1A2, CYP2D6 and CYP3A4 enzymes. J Ethnopharmacol. 2018 Jan 30;211:58-69. doi: 10.1016/j.jep.2017.09.023. Epub 2017 Sep 21.

 

  1. Reay R, Dandara C, Viljoen M, Rheeders M. CYP2B6 Haplotype Predicts Efavirenz Plasma Concentration in Black South African HIV-1-Infected Children: A Longitudinal Pediatric Pharmacogenomic Study. OMICS. 2017 Aug;21(8):465-473. doi: 10.1089/omi.2017.0078.

 

  1. Mhandire K, Zijenah LS, Yindom LM, Duri K, Mlambo T, Tshabalala M, Mazengera LR, Mhandire DZ, Musarurwa C, Dandara C, Rowland-Jones S, Matarira HT, Stray-Pedersen B. KIR Gene Content Diversity in a Zimbabwean Population: Does KIR2DL2 Have a Role in Protection Against Human Immunodeficiency Virus Infection? OMICS. 2016 Dec;20(12):727-735.

 

  1. Dandara C, Özdemir V. Precision Medicine 2.0: The Next Wave of Science. OMICS. 2016 Oct;20(10):555-556

 

  1. Barlas İÖ, Sezgin O, Dandara C, Türköz G, Yengel E, Cindi Z, Ankaralı H, Şardaş S. Harnessing Knowledge on Very Important Pharmacogenes CYP2C9 and CYP2C19 Variation for Precision Medicine in Resource-Limited Global Conflict Zones. OMICS. 2016 Oct;20(10):604-609.

 

  1. Thomford NE, Mkhize B, Dzobo K, Mpye K, Rowe A, Parker MI, Wonkam A, Skelton M, September AV, Dandara C. African Lettuce (Launaea taraxacifolia) Displays Possible Anticancer Effects and Herb-Drug Interaction Potential by CYP1A2, CYP2C9, and CYP2C19 Inhibition. OMICS. 2016 Sep;20(9):528-37. doi: 10.1089/omi.2016.0117.

 

  1. Soko ND, Masimirembwa C, Dandara C. Pharmacogenomics of Rosuvastatin: A Glocal (Global+Local) African Perspective and Expert Review on a Statin Drug. OMICS. 2016 Sep;20(9):498-509. doi: 10.1089/omi.2016.0114. Review.

 

  1. Mpeta B, Kampira E, Castel S, Mpye KL, Soko ND, Wiesner L, Smith P, Skelton M, Lacerda M, Dandara C. Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans. Pharmacogenomics. 2016 May;17(7):679-90. doi: 10.2217/pgs.16.14. Epub 2016 May 4.

 

  1. Thomford NE, Dzobo K, Chopera D, Wonkam A, Maroyi A, Blackhurst D, Dandara C. In Vitro Reversible and Time-Dependent CYP450 Inhibition Profiles of Medicinal Herbal Plant Extracts Newbouldia laevis and Cassia abbreviata: Implications for Herb-Drug Interactions. Molecules. 2016 Jul 7;21(7). pii: E891. doi: 10.3390/molecules21070891

 

  1. Soko N, Dandara C, Ramesar R, Kadzirange G, Masimirembwa C. Pharmacokinetics of rosuvastatin in 30 healthy Zimbabwean individuals of African ancestry. Br J Clin Pharmacol. 2016 Jul;82(1):326-8. doi: 10.1111/bcp.12915.

 

  1. Thomford NE, Awortwe C, Dzobo K, Adu F, Chopera D, Wonkam A, Skelton M, Blackhurst D, Dandara C. Inhibition of CYP2B6 by Medicinal Plant Extracts: Implication for Use of Efavirenz and Nevirapine-Based Highly Active Anti-Retroviral Therapy (HAART) in Resource-Limited Settings. Molecules. 2016 Feb 16;21(2). pii: E211. doi: 10.3390/molecules21020211.

 

  1. Pinillos F, Dandara C, Swart M, Strehlau R, Kuhn L, Patel F, Coovadia A, Abrams E. Case report: Severe central nervous system manifestations associated with aberrant efavirenz metabolism in children: the role of CYP2B6 genetic variation. BMC Infect Dis. 2016 Feb 2;16:56. doi: 10.1186/s12879-016-1381-x.

 

  1. Swart M, Evans J, Skelton M, Castel S, Wiesner L, Smith PJ, Dandara C. An Expanded Analysis of Pharmacogenetics Determinants of Efavirenz Response that Includes 3'-UTR Single Nucleotide Polymorphisms among Black South African HIV/AIDS Patients. Front Genet. 2016 Jan 7;6:356. doi: 10.3389/fgene.2015.00356. eCollection 2015.

 

  1. Chattopadhyay K, Williamson AL, Hazra A, Dandara C. The combined risks of reduced or increased function variants in cell death pathway genes differentially influence cervical cancer risk and herpes simplex virus type 2 infection among black Africans and the Mixed Ancestry population of South Africa. BMC Cancer. 2015 Oct 12;15:680. doi: 10.1186/s12885-015-1678-y.

 

  1. Evans J, Swart M, Soko N, Wonkam A, Huzair F, Dandara C. A Global Health Diagnostic for Personalized Medicine in Resource-Constrained World Settings: A Simple PCR-RFLP Method for Genotyping CYP2B6 g.15582C>T and Science and Policy Relevance for Optimal Use of Antiretroviral Drug Efavirenz. OMICS. 2015 Jun;19(6):332-8. doi: 10.1089/omi.2015.0039.

 

  1. Thomford NE, Dzobo K, Chopera D, Wonkam A, Skelton M, Blackhurst D, Chirikure S, Dandara C. Pharmacogenomics Implications of Using Herbal Medicinal Plants on African Populations in Health Transition. Pharmaceuticals (Basel). 2015 Sep 21;8(3):637-63. doi: 10.3390/ph8030637.

 

  1. Mhandire D, Lacerda M, Castel S, Mhandire K, Zhou D, Swart M, Shamu T, Smith P, Musingwini T, Wiesner L, Stray-Pedersen B, Dandara C. Effects of CYP2B6 and CYP1A2 Genetic Variation on Nevirapine Plasma Concentration and Pharmacodynamics as Measured by CD4 Cell Count in Zimbabwean HIV-Infected Patients. OMICS. 2015 Sep;19(9):553-62. doi: 10.1089/omi.2015.0104.

 

  1. Dandara C, Robertson B, Dzobo K, Moodley L, Parker MI. Patient and tumour characteristics as prognostic markers for oesophageal cancer: a retrospective analysis of a cohort of patients at Groote Schuur Hospital. Eur J Cardiothorac Surg. 2016 Feb;49(2):629-34. doi: 10.1093/ejcts/ezv135. Epub 2015 Apr 12.

 

  1. Mhandire K, Duri K, Kandawasvika G, Chandiwana P, Chin'ombe N, Kanyera RB, Stray-Pedersen B, Dandara C. CCR2, CX3CR1, RANTES and SDF1 genetic polymorphisms influence HIV infection in a Zimbabwean pediatric population. J Infect Dev Ctries. 2014 Oct 15;8(10):1313-21. doi: 10.3855/jidc.4599.

 

  1. Carr DF, Chaponda M, Cornejo Castro EM, Jorgensen AL, Khoo S, Van Oosterhout JJ, Dandara C, Kampira E, Ssali F, Munderi P, Lalloo DG, Heyderman RS, Pirmohamed M. CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. J Antimicrob Chemother. 2014 Dec;69(12):3329-34. doi: 10.1093/jac/dku315. Epub 2014 Aug 20.

 

  1. Swart M, Dandara C. Genetic variation in the 3'-UTR of CYP1A2, CYP2B6, CYP2D6, CYP3A4, NR1I2, and UGT2B7: potential effects on regulation by microRNA and pharmacogenomics relevance. Front Genet. 2014 Jun 4;5:167. doi: 10.3389/fgene.2014.00167. eCollection 2014.

 

  1. Kampira E, Dzobo K, Kumwenda J, van Oosterhout JJ, Parker MI, Dandara C. Peripheral blood mitochondrial DNA/nuclear DNA (mtDNA/nDNA) ratio as a marker of mitochondrial toxicities of stavudine containing antiretroviral therapy in HIV-infected Malawian patients. OMICS. 2014 Jul;18(7):438-45. doi: 10.1089/omi.2014.0026. Epub 2014 May 9.

 

  1. Mhandire K, Pharo G, Kandawasvika GQ, Duri K, Swart M, Stray-Pedersen B, Dandara C.
    How does mother-to-child transmission of HIV differ among African populations? Lessons from MBL2 genetic variation in Zimbabweans. OMICS. 2014 Jul;18(7):454-60. doi: 10.1089/omi.2013.0131. Epub 2014 Mar 6.

 

  1. Dandara C, Swart M, Mpeta B, Wonkam A, Masimirembwa C. Cytochrome P450 pharmacogenetics in African populations: implications for public health. Expert Opin Drug Metab Toxicol. 2014 Jun;10(6):769-85. doi: 10.1517/17425255.2014.894020. Epub 2014 Mar 3. Review.

 

  1. Bienvenu E, Swart M, Dandara C, Ashton M. The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs and on efavirenz plasma levels in adult HIV patients. Antiviral Res. 2014 Feb;102:44-53. doi: 10.1016/j.antiviral.2013.11.011. Epub 2013 Dec 5.

 

  1. Kampira E, Kumwenda J, Van Oosterhout JJ, Dandara C. Mitochondrial subhaplogroups and differential risk of stavudine-induced lipodystrophy in Malawian HIV/AIDS patients. Pharmacogenomics. 2013 Dec;14(16):1999-2004. doi: 10.2217/pgs.13.188

 

  1. Swart M, Skelton M, Ren Y, Smith P, Takuva S, Dandara C. High predictive value of CYP2B6 SNPs for steady-state plasma efavirenz levels in South African HIV/AIDS patients. Pharmacogenet Genomics. 2013 Aug;23(8):415-27. doi: 10.1097/FPC.0b013e328363176f.

 

  1. Swart M, Whitehorn H, Ren Y, Smith P, Ramesar RS, Dandara C. PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in South African HIV/AIDS patients. BMC Med Genet. 2012 Nov 22;13:112. doi: 10.1186/1471-2350-13-112.

 

  1. Swart M, Ren Y, Smith P, Dandara C. ABCB1 4036A>G and 1236C>T Polymorphisms Affect Plasma Efavirenz Levels in South African HIV/AIDS Patients. Front Genet. 2012 Nov 5;3:236. doi: 10.3389/fgene.2012.00236. eCollection 2012

 

  1. Dandara C, Lombard Z, Du Plooy I, McLellan T, Norris SA, Ramsay M. Genetic variants in CYP (-1A2, -2C9, -2C19, -3A4 and -3A5), VKORC1 and ABCB1 genes in a black South African population: a window into diversity. Pharmacogenomics. 2011 Dec;12(12):1663-70. doi: 10.2217/pgs.11.106.

 

  1. Warnich L, Drögemöller BI, Pepper MS, Dandara C, Wright GE. Pharmacogenomic Research in South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation. Curr Pharmacogenomics Person Med. 2011 Sep;9(3):191-207.