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Pharmacogenomics

Publications

(2010-present)

1. Collen Masimirembwa, Collet Dandara, Julia Hasler. (Book Chapter)  Population Diversity and Pharmacogenomics in Africa. (Book title) Handbook of Pharmacogenomics and Stratified Medicines. Elsevier. 2014, pp971-996

2. Elizabeth Kampira, Kevin Dzobo, Johnstone Kumwenda, Joep  J van Oosterhout, M. Iqbal Parker, and Collet Dandara Peripheral blood mitochondrial DNA/nuclear DNA (mtDNA/nDNA) ratio as a marker of mitochondrial toxicities of stavudine containing antiretroviral therapy in HIV-infected Malawian patients. OMICS 2014, May 12

3. Bosch  J,  Lebeko  K, Noubiap J, Dandara C, Makubalo N, Wonkam A.  In search of genetic markers for non-syndromic deafness in Africa: A study in Cameroonians and Black South Africans with the GJB6 and GJA1 candidate genes. OMICS 2014, May 2

4. Ozdemir V, Endrenyi L, Aynacıoğlu S, Bragazzi NL, Dandara C, Dove ES, Ferguson LR, Geraci CJ, Hafen E, Kesim BE, Kolker E, Lee EJ, Llerena A, Nacak M, Shimoda K, Someya T, Srivastava S, Tomlinson B, Vayena E, Warnich L, Yaşar U. Bernard Lerer: Recipient of the 2014 Inaugural Werner Kalow Responsible Innovation Prize in Global Omics and Personalized Medicine (Pacific Rim Association for Clinical Pharmacogenetics). OMICS 2014

5. Michelle M Skelton, Elizabeth E Kampira, Ambroise A Wonkam, Kudakwashe K Mhandire, Johnstone J Kumwenda, Kerina K Duri,  Collet C Dandara . Frequency variation among Sub-Saharan population in virus restriction gene,BST2 proximal promoter polymorphisms: implications for HIV-1 prevalence differences among African countries. OMICS 2014,  March 6

6. Kudakwashe Mhandire, Gavin Pharo, Gwendolene Q Kandawasvika, Kerina Duri, Marelize Swart, Babill Stray-Pedersen, Collet Dandara. How does Mother to Child transmission of HIV differ among African populations? Lessons from MBL2 Genetic Variation in Zimbabweans. OMICS: A Journal of Integrative Biology 2014

7. Collet Dandara, Marelize Swart, Bafokeng Mpeta, Ambroise Wonkam, Collen Masimirembwa.  CYP pharmacogenetics variations in African populations: implications for public health. Expert Opin Drg Metab Toxicol 2014; 10(5)

8. Emile Bienvenue, Marelize Swart, Collet Dandara, Michael Ashton. The role of genetic polymorphisms in cytochrome P450 and effects of tuberculosis co-treatment on the predictive value of CYP2B6 SNPs on efavirenz plasma levels in Rwandan adult HIV patients. Antiviral Research 2014; 102C:44-53

9. Ian Louis Ross, Collet Dandara, Marelize Swart, Miguel Lacerda, Desmond Schatz, Dirk Jacobus Blom. 9β Polymorphism of the Glucocorticoid Receptor Gene Appears to Have Limited Impact in Patients with Addison’s disease. Plos One 2014; 9(1): e86350

10.Vural O¨ zdemir, Eugene Kolker, Peter J. Hotez, Sophie Mohin, Barbara Prainsack, Brian Wynne, Effy Vayena, Yavuz Cosxkun, Tu¨ rkay Dereli, Farah Huzair, Alexander Borda-Rodriguez, Nicola Luigi Bragazzi, Jack Faris, Raj Ramesar, Ambroise Wonkam, Collet Dandara, Bipin Nair,  Adria´n LLerena, Koray Kılıc¸ Rekha Jain, Panga Jaipal Reddy, Kishore Gollapalli, Sanjeeva Srivastava, and Ilona Kickbusch . Ready to Embrace Metadata for the Post-2015 Development Agenda? Linking Data Publications to Responsible Innovation and Science Diplomacy. OMICS JIB 2014;18(1):1-9

11. Elizabeth Kampira, Johnstone Kumwenda, Joep J van Oosterhout, Collet Dandara. Mitochondria subhaplogroups are associated with differential risk of stavudine associated lipodystrophy. Pharmacogenomics (2013) 14(16):1999-2004 (December 2013 Issue)

12. Emile Bienvenu, Marelize Swart, Collet Dandara, Agneta Ekman, Angela Äbelö, Ambroise Wonkam, Michael Ashton. Frequencies of Single Nucleotide Polymorphisms in Cytochrome P450 Genes (CYP1A2, 2A6, 2B6, 3A4 and 3A5) in a Rwandan Population: Difference to Other African Populations. Current Pharmacogenomics and Personalised Medicine 2013; 11(3) (published)

13. M Swart, M Skelton, Y Ren, P Smith, C Dandara. High predictive value of CYP2B6 SNPs for steady-state

14. plasma efavirenz levels in South African HIV/AIDS patients. Pharmacogenet Genomics. 2013 Aug;23(8):415-27.

15. Elizabeth Kampira,  Johnstone Kumwenda, Joep  J van Oosterhout, Collet Dandara. Mitochondrial DNA subhaplogroups Loa2 and L2a modify susceptibility to Peripheral Neuropathy in HIV/AIDS patients on stavudine containing highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2013 August 15; 6395)415-27

16. Ambroise Wonkam, Jean Jacques Noubiap Nzeale, Jason Bosch, Collet Dandara, Geneviève Bengono Toure; Heterozygous D50N mutation in the GJB2 gene in two Cameroonian patients with Keratitis-Ichthyosis-Deafness (KID) syndrome. BMC Med Genet. 2013 Aug 7;14:81. doi: 10.1186/1471-2350-14-81.

17. C Dandara, J Greenberg, L Lambie, Z Lombard, T Naicker, R Ramesar, M Ramsay, L Roberts, M Theron, P Venter and S Bardien. Direct-to-consumer genetic testing: To test or not to test, that is the question. S Afr Med J 2013 Jul 4;103(8):510-2. doi: 10.7196/samj.7049

18. Ross IL, Levitt NS, Van der Merwe L, Schatz DA, Johannson G, Dandara C, Pillay T, Blom D. The Effect of Glucocorticoid Receptor Polymorphisms on the Sensitivity to Cortisol in Addison’s disease. Eur J Endocrinol first published on 12 December 2012, doi:10.1530/EJE-12-0808

19. Marelize Swart, Heather Whitehorn, Yuan Ren, Pete Smith, Rajkumar S Ramesar, Collet Dandara. PXR and CAR single nucleotide polymorphisms influence plasma efavirenz levels in HIV/AIDS patients. BMC Medical Genetics 2012 Nov 22;13(1):112.

20.Marelize Swart, Yuan Ren, Pete Smith, Collet Dandara.  ABCB1 4036A>G and 1236C>T polymorphisms affect plasma efavirenz levels in South African HIV/AIDS patients. Frontiers in Genetics 2012;3:236. Epub 2012 Nov 5.

21. Collet Dandara, Chris Scott, Mike Urban, Karen Fieggen, Regan Arendse, Peter Beighton. Confirmation of the recurrent acvr1 617G A mutation in South Africans with fibrodysplasia ossificans progressiva. SAMJ 2012;631-633

22. kinyi MV, Dandara C, Gamieldien J, Heckmann, JM.  Association of Transforming Growth Factor Beta (TGFB1) regulatory region polymorphisms with the development of Myasthenia Gravis-related ophthalmoparesis. Journal of Neuroimmunology  2012 May 15;246(1-2):96-9.

23. (Editorial); Collet Dandara, Peter J. Hotez, Bartha M. Knoppers, Richard A. Gibbs, Mikkel Z. Ostergaard, Jantina de Vries, Edward S. Dove, Tikki Pang, Charles N. Rotimi and Clement Adebamowo. An Idea Whose Time Has Come? An African Foresight Observatory on Genomics Medicine and Data-Intensive Global Science. Curr Pharmacogenomics Person Med 2012;10(1):7-15

24. Marelize Swart, Michelle Skelton, Ambroise Wonkam, Luke Kannemeyer, Nyasha Chin’ombe, Collet Dandara. CYP1A2, CYP2A6, CYP2B6 and CYP3A4/5 polymorphisms in two Bantu populations from Cameroon and South Africa: pharmacogenetics implications. Curr Pharmacogenomics Person Med 2012; 10(1): 43-53.

25. Elizabeth Kampira, Johnstone Kumwenda, Joep J van Oosterhout, Mas Chaponda and Collet Dandara. Pharmacogenetics Research Developments in Africa: A Focus on Malawi. Curr Pharm Person Med 2012; 10(1):87-97

26. Viljoen M, Karlsson MO, Meyers TM, Gous H, Dandara C, Rheeders M. Influence of CYP2B6 516G>T polymorphism and interoccasion variability (IOV) on the population pharmacokinetics of efavirenz in HIV-infected South African children.  Eur J Clin Pharmacol. 2012 Apr;68(4):339-47

27. Collet Dandara, Zané Lombard, Ingrid Du Plooy, Tracy McLellan, Shane Norris, Michèle Ramsay. Genetic variants in CYP genes (1A2, 2C9, 2C19, 3A4, and 3A5), VKORC1 and ABCB1 in a Black South African population:  A window into diversity. Pharmacogenomics 2011; 12:1663-1670

28. Louise Warnich, Britt I. Drögemöller, Michael S. Pepper, Collet Dandara and Galen E.B. Wright Pharmacogenomic Research In South Africa: Lessons Learned and Future Opportunities in the Rainbow Nation.  Current Pharmacogenomics and Personalized Medicine  2011:;9:191-207

29. Strehlau R, Martens L, Coovadia A, Dandara C, Norman J, Maisel J, Kuhn L, Abrams EJ. Absence Seizures Associated With Efavirenz Initiation. Pediatr Infect Dis J. 2011; May 31. [Epub ahead of print]

30. Koushik Chatterjee, Anna-Lise Williamson, Margaret Hoffman and  Collet Dandara.  CASP8 Promoter Polymorphism Is Associated With High-Risk HPV Types and Abnormal Cytology But Not With Cervical Cancer. J Med Virol 2011; 83:630-6. doi: 10.1002/jmv.22009

31. Chris Scott, Mike Urban, Reagan Arendse, Collet Dandara, Peter Beighton. Fibrodysplasia Ossificans Progressiva in South Africa: Difficulties in management in a developing country.  Journal of Clinical Rheumatology 2011; 17:37-41

32. Koushik Chatterjee, Collet Dandara, Ulf Gyllensten, Lize van der Merwe, Ushma Galal, Margaret Hoffman, Anna-Lise Williamson1, A Fas Gene Polymorphism Influences Herpes Simplex Virus Type 2 Infection In South African Women. Journal of Medical Virology 2010:82;2082-6

33. Li D, Dandara C, Parker MI. The 341C/T polymorphism in the GSTP1 gene is associated with increased risk of oesophageal cancer. BMC Genet 11(1):47

34. Chatterjee K, Dandara C, Hoffman M, Williamson AL.CCR2-V64I polymorphism is associated with increased risk of cervical cancer but not with HPV infection or pre-cancerous lesions in African women. BMC Cancer 2010; 10(1):278.